?v=1.0 Transcenta Announces First Patient Dosed in Phase Ib Clinical Trial of its Humanized Anti-VEGFR-2 Monoclonal Antibody MSB0254-TRANSCENTA HOLDING - A global Fully Integrated Biotherapeutics Company

TRANSCENTA HOLDING - A global Fully Integrated Biotherapeutics Company

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TRANSCENTA HOLDING - A global Fully Integrated Biotherapeutics Company

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Transcenta Announces First Patient Dosed in Phase Ib Clinical Trial of its Humanized Anti-VEGFR-2 Monoclonal Antibody MSB0254

25 Nov, 2021

SUZHOU, China, November 25, 2021, Transcenta Holding Limited ("Transcenta") (HKEX: 06628), a clinical stage biopharmaceutical company with fully-integrated capabilities in discovery, research, development and manufacturing of antibody-based therapeutics, announces the successful dosing of first patient in Phase Ib Clinical Trial of MSB0254, a humanized anti-VEGFR-2 monoclonal antibody. MSB0254 has previously completed a Phase Ia clinical trial and established a Recommended Phase II Dose (RP2D). 

The aim of the study is to evaluate the safety, tolerability, PK, and anti-tumor activity of MSB0254 at RP2D dose in multiple solid tumor types including neuroendocrine tumor, hepatocellular carcinoma and others.

MSB0254 is a high affinity humanized anti-VEGFR-2 mAb, with an anti-tumor mechanism of action by inhibiting tumor angiogenesis. MSB0254 has been generated using Transcenta’s in-house antibody discovery platform. Inhibition of angiogenic pathways has been well validated as an effective approach for the treatment of cancer and has shown promise in modulating immune microenvironment and enhancing the activities of immunotherapy. Transcenta will explore the potential of MSB0254 as a single agent or in combination with other compounds, including Transcenta pipeline molecules such as TST001 and TST005.


About MSB0254

MSB0254 is a high affinity humanized anti-VEGFR-2 mAb, with an anti-tumor mechanism of action by inhibiting tumor angiogenesis. MSB0254 has been generated using Transcenta’s in-house antibody discovery platform. VEGFR-2 is overexpressed in neovascular tumor endothelial cells in many tumors in comparison to normal endothelial cells. Vascular permeability, survival and migration of the vascular endothelial cells are controlled by the VEGFR-2 pathway. VEGFR-2 inhibitors has been shown to be able to inhibit tumor-induced angiogenesis and effectively block tumor growth, and thus may have a potential therapeutic role in multiple tumor types.


About Transcenta Holding Limited

Transcenta (HKEX: 06628) is a clinical stage biopharmaceutical company with fully integrated capabilities in antibody-based biotherapeutics discovery, research, development and manufacturing. 

Transcenta has established global footprint, with Headquarters and Discovery, Clinical and Translational Research Center in Suzhou, Process and Product Development Center and Manufacturing Facility in Hangzhou, and Clinical Development Centers in Beijing, Shanghai and Guangzhou in China and in Princeton, US, and External Partnering Center in Boston and Los Angeles, US. Transcenta is developing nine therapeutic antibody molecules for oncology and selected non-oncology indications including bone and kidney disorders. 

For more information, please visit www.transcenta.com and https://www.linkedin.com/company/transcenta.


Forward-Looking Statements

This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words "anticipate", "believe", "estimate", "expect", "intend" and similar expressions, as they relate to Transcenta, are intended to identify certain of such forward-looking statements. Transcenta does not intend to update these forward-looking statements regularly.

These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of Transcenta with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond Transcenta's control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, Transcenta's competitive environment and political, economic, legal and social conditions.

Transcenta, the Directors and the employees of Transcenta assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialize or turn out to be incorrect.


Contacts

Investor Relations: ir@transcenta.com

Public Relations: pr@transcenta.com

Business Development: bd@transcenta.com